Organic Cation Transporter 3 Facilitates Fetal Exposure to Metformin during Pregnancy

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Association between the synonymous variant organic cation transporter 3 (OCT3)-1233G>A and the glycemic response following metformin therapy in patients with type 2 diabetes

Objective(s): Organic cation transporter 3 (OCT3) as a high-capacity transporter contribute to the metabolism of metformin. The present study was conducted to determine the genotype frequencies of the variant OCT3-1233G>A (rs2292334) in patients with newly diagnosed type 2 diabetes (T2D) and its relationship with response to metformin. Materials and Methods: This study included 150 patients wit...

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Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin.

OBJECTIVES The goals of this study were to determine the role of organic cation transporter 3 (OCT3) in the pharmacological action of metformin and to identify and functionally characterize genetic variants of OCT3 with respect to the uptake of metformin and monoamines. METHODS For pharmacological studies, we evaluated metformin-induced activation of AMP-activated protein kinase, a molecular ...

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Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action.

Metformin is among the most widely prescribed drugs for the treatment of type 2 diabetes. Organic cation transporter 1 (OCT1) plays a role in the hepatic uptake of metformin, but its role in the therapeutic effects of the drug, which involve activation of AMP-activated protein kinase (AMPK), is unknown. Recent studies have shown that human OCT1 is highly polymorphic. We investigated whether OCT...

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ژورنال

عنوان ژورنال: Molecular Pharmacology

سال: 2018

ISSN: 0026-895X,1521-0111

DOI: 10.1124/mol.118.112482